Publications

  • Albrecht, L.V, Tejeda-Muñoz, N. and De Robertis, E.M. (2021). Cell biology of canonical Wnt signaling. Annu. Rev. Cell Dev. Biol., 37, 369-389 PMID: 34196570
  • De Robertis, E.M. and Tejeda-Muñoz, N. (2021). Signaling Components in Dorsal-Ventral Patterning and the Organizer in Xenopue. In: Xenopus, from basic biology to disease models in the genomic era. S. A. Moody and A. Fainsod, Eds. Taylor and Francis CRC Press, in press.
  • Zhang, F., Zhu, X., Wang, P., He, Q. Huang, H., Zheng, T. Li, Y., Jia, H., Xu, L., Zhao, H., Colozza, G., Tao, Q.*, De Robertis, E.M*. and Ding, Y.* (2021). The Cytokine FAM3B/PANDER is an FGFR Ligand that Promotes Posterior Development in Xenopus. Proc. Natl. Acad. Sci. U.S.A., in press. *Corresponding authors.
  • De Robertis, E.M. and Gurdon, J.B. (2021). A brief history of Xenopus in biology. Cold Spring Harb. Protoc.
  • Niehrs, C. (2021). Lessons from the Organizer – an interview with Edward M. (Eddy) De Robertis. Int. J. Dev. Biol. 65, 111-122.

Ding, Y., Colozza, G., Sosa, E.A., Moriyama, Y., Rundle, S., Salwinski, L. and De Robertis, E.M. (2018). Bighead is a novel Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. Proc. Natl. Acad. Sci. USA 115, E9135-E9144.

De Robertis, E.M. (2018). Regulation of protein degradation by Wnt signaling. Pontif. Acad. Sci. Scripta Varia 137, 177-186.

De Robertis, E.M. and Sanchez Sorondo, M., Eds. (2018). Cell Biology and Genetics. Pontificiae Academiae Scientarum Scripta Varia vol. 137, Libreria Editrice Vaticana, Rome, 330 pp.

Albrecht, L., Ploper, D., Tejeda-Munoz, N and De Robertis, E.M. (2018). Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking. Proc. Natl. Acad. Sci. USA, 115. E5317-E5325.

Moriyama, Y. and De Robertis, E.M. (2018). Twinning: Embryonic regeneration by relocalization of the Spemann organizer in Xenopus. Proc. Natl. Acad. Sci. USA, 115, E4815-E4822.

  • De Robertis, E.M. (2014). Deciphering Complexity in Biology: Induction of Embryonic Cell Differentiation by Morphogen Gradients. Pontif. Acad. Sci. Acta 22.
  • De Robertis, E.M. (2014). Lessons from a great developmental biologist. Differentiation 88, 3-8.
  • De Robertis, E.M. and Niehrs, C. (2014). Herbert Steinbeisser: a life with the Xenopus embryo. Int. J. Dev. Biol. 58, 299-302.
  • De Robertis, E. M. (2014). Yoshiki Sasai 1962-2014. Cell 158, 1233-1235. See also Dev. Cell 30, 509-511.
  • Demagny, H., Araki, T. and De Robertis, E.M. (2014). The tumor suppressor Smad4/DCP4 is at the crossroads of Wnt, FGF and TGF-β signaling.  Cell Reports 9, 1-13.
  • Colozza, G. and De Robertis, E.M. (2014). Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus. Differentiation, 10.1016/j.diff.2014.03.002.
  • Plouhinec, J.L., Zakin, L., Moriyama, Y. and De Robertis, E.M. (2013). Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo. Proc. Natl. Acad. Sci. U.S.A. 110, 20372-20379.
  • De Robertis, E.M. and Colozza, G. (2013). Development: Scaling to size by protease inhibition. Curr. Biol. 23, R652-R654.
  • Dobrowolski, R., Vick, P., Ploper, D., Gumper, I., Snitkin, H., Sabatini, D.D. and De Robertis, E.M. (2012). Presenilin deficiency or lysosomal inhibition enhance Wnt signaling through relocalization of GSK3 to the late endosomal compartment. Cell Reports 2, 1316-1328.
  • Dobrowolski, R. and De Robertis, E.M. (2012). Endocytic control of growth factor signaling: multivesicular bodies as signaling organelles. Nat. Rev. Mol. Cell Biol. 13, 53-60.
  • Eivers, E., Demagny, H., Choi, R.H. and De Robertis, E.M. (2011). Phosphorylation of Mad controls competition between Wingless and BMP signaling.  Science Signaling 4, ra68.
  • Taelman, V.F., Dobrowolski, R., Plouhinec, J.L., Fuentealba, L.C., Vorwald, P.P., Gumper, I., Sabatini, D.D. and De Robertis, E.M. (2010). Wnt signaling requires the sequestration of Glycogen Synthase kinase 3 inside Multivesicular Bodies. Cell 143, 1136-1148.
  • Zakin, L., Chang, E.Y. and De Robertis, E.M. (2010). Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. Dev. Biol. 347, 204-215.
  • De Robertis, E.M. (2010). Wnt signaling in axial patterning and regeneration: Lessons from Planaria. Sci. Signal. 3, pe21.
  • Sander, V., Eivers, E., Choi, R.H. and De Robertis, E.M. (2010) Drosophila Smad2 opposes Mad signaling during wing vein development. PLoS ONE 5, e10383.
  • Tran, U., Zakin, L., Schweickert, A., Agrawal, R., Döger, R., Blum, M., De Robertis, E.M. and Wessely, O. (2010). The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development 137, 1107-1116.
  • Zakin, L. and De Robertis, E.M. (2010). Extracellular regulation of BMP signaling. Current Biol. 20, R89-R92.
  • Eivers, E., Demagny, H. and De Robertis, E.M. (2009). Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. Cytokine Growth F. R. 20, 357-365.
  • Lee, H.X., Mendes, F.A., Plouhinec, J.L. and De Robertis, E.M. (2009). Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.  Genes Dev. 23, 2551-2562.
  • De Robertis, E.M. (2009). Spemann’s organizer and the self-regulation of embryonic fields. Mech. Dev. 126, 925-941.
  • Fuentealba, L.C., Eivers, E., Lee, H.X. and De Robertis, E.M. (2009). Integration of BMP, RTK, and Wnt signaling through Smad 1 phosphorylations.  In: Handbook of Cell Signaling, 2nd edition, R. A. Bradshaw and E. A. Dennis, Eds., Academic Press, Oxford, pages 1989-1994.
  • Eivers, E., Fuentealba, L.C., Sander, V., Clemens, J., Hartnett, L. and De Robertis, E.M. (2009) Mad is required for Wingless signaling and segment patterning in Drosophila and Xenopus. PLoS ONE 4, e6543.
  • Plouhinec, J.L. and De Robertis, E.M. (2009). Systems biology of the self-regulating morphogenetic gradient of the Xenopus gastrula. In: Reading and Interpreting Gradients during Development. J. Briscoe, P. Lawrence and J.P. Vincent, Eds., Cold Spring Harb. Perspect. Biol., doi: 10.1101/cshperspect.a001701.
  • De Robertis, E.M. (2008). Evolutionary Biology Commentary: The molecular ancestry of segmentation mechanisms. Proc. Natl. Acad. Sci. USA 105, 16411-16412.
  • Zakin, L., Metziner, C.A., Chang, E.Y., Coffinier, C. and De Robertis, E.M. (2008). Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted gastrulation. Dev. Biol.323, 6-18 .
  • Ambrosio, A.L., Taelman, V.F., Lee, H.X., Metzinger, C.A., Coffinier, C. and De Robertis, E.M. (2008). Crossveinless-2 is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Dev. Cell 15, 248-260.
  • Eivers, E., Fuentealba, L.C. and De Robertis, E.M. (2008). Integrating positional information at the level of Smad1/5/8. Curr. Opin. Genet. Dev. 18, 1-7.
  • Fuentealba, L.C., Eivers, E., Geissert, D., Taelman, V. and De Robertis, E.M. (2008). Asymmetric mitosis: Unequal segregation of proteins destined for degradation. PNAS 105, 7732-7737.
  • De Robertis, E.M. (2008). Evo-Devo: Variations on Ancestral themes. Cell 132, 185-195.
  • Ishibashi, H., Matsumura, N., Hanafusa, H., Matsumoto, K, De Robertis, E.M. and Kuroda, H. (2008). Expression of Siamois and Twin in the blastula chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos. Mech. Dev. 125, 58-66.
  • Fuentealba, L.C., Eivers, E., Ikeda, A., Hurtado, C., Kuroda, H., Pera, E.M., and De Robertis, E.M. (2007). Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131, 980-993.
  • Yasuda, S., Tanaka, H., Sugiura, H., Okamura, K., Sakaguchi, T., Tran, U., Takemiya, T., Mizoguchi, A., Yagita, Y., Sakurai, T., De Robertis, E.M. and Yamagata, K. (2007). Arcadlin, a synaptic activity-induced protocadherin, regulates dendritic spine number by triggering N-Cadherin endocytosis via TAO2β and p38 MAP kinases. Neuron 56, 456-471.
  • Hurtado, C. and De Robertis, E.M. (2007). Neural induction in the absence of organizer in salamanders is mediated by Ras/MAPK. Dev. Biol. 307, 282-289.
  • Plouhinec, J.-L. and De Robertis, E.M. (2007) Systems biology of embryonic morphogens. Molecular BioSystems 3, 454-457.
  • Sander, V., Reversade, B. and De Robertis, E.M. (2007). The opposing homebox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. EMBO J. 26, 2955-2965.
  • Lee, H.X., Ambrosio, A.L., Reversade, B. and De Robertis, E.M. (2006). Embryonic dorsal-ventral signaling: secreted Frizzled-related proteins as inhibitors of Tolloid proteinases. Cell 124, 147-159.
  • De Robertis, E.M. (2006). Spemann’s organizer and self-regulation in amphibian embryos. Nature Reviews Molecular Cell Biology 7, 296-302.
  • Reversade, B. and De Robertis, E.M. (2005). Formation of a self-differentiating morphogenetic field via reciprocal regulation of Admp and Bmp2/4/7 at opposite poles of the Xenopus embryo. Cell 123, 1147-1160.
  • Zakin, L., Reversade, B., Kuroda, H., Lyons, K.M. and De Robertis, E.M. (2005). Sirenomelia in Bmp7 and Twisted gastrulation composed mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development 132, 2489-2499.
  • Kuroda, H., Fuentealba, L., Ikeda, A., Reversade, B. and De Robertis, E.M. (2005). Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes Dev. 19, 1022-1027 .
  • Wessely, O., Kim, J.I., Tran, U., Fuentealba, L. and De Robertis, E.M. (2005). xBtg-x regulates Wnt/ b -Catenin signaling during early Xenopus development. Dev. Biol. 283, 17-28 .
  • Reversade, B., Kuroda, H., Lee, H., Mays, A. and De Robertis, E.M. (2005). Depletion of BMP2, 4, 7 and Spemann organizer signals induces massive brain formation in Xenopus embryo. Development 132, 3381-3392.
  • Pera, E.M., Hou, S., Strate, I., Wessely, O. and De Robertis, E.M. (2005). Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo. Int. J. Dev. Biol. 49, 781-796.
  • Oelgeschläger, M., Kuroda, H., Reversade, B. and De Robertis, E.M. (2003). Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Developmental Cell 4, 219-230.
  • Pera, E.M., Martínez, S.L., Flanagan, J.J., Brechner, M., Wessely, O. and De Robertis, E.M. (2003). Darmin is a novel secreted protein expressed during endoderm development in Xenopus. Gene Exp. Patterns, Mech. Dev. 3, 147-152.
  • Bachiller, D., Klingensmith, J., Schneyder, N., Tran, U., Anderson, R., Rossant, J. and De Robertis, E.M. (2003). The role of Chordin/BMP signals in mammalian pharyngeal development and DiGeorge syndrome. Development 130, 3567-3578.
  • Oelgeschläger, M., Reversade, B., Larraín, J., Little, S., Mullins, M.C. and De Robertis, E.M. (2003). The pro-BMP activity of Twisted gastrulation is independent of BMP binding. Development 130, 4047-4056.
  • Larraín, J., Brown, C. and De Robertis, E.M. (2003). Integrin-a3 mediates binding of Chordin to the cell surface and promotes its endocytosis. EMBO reports 4, 813-818.
  • Pera, E.M., Ikeda, A., Eivers, E. and De Robertis, E.M. (2003). Integration of IGF, FGF and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev. 17, 3023-3028.
  • Coffinier, C., Tran, U., Larraín, J. and De Robertis, E.M. (2001). Neuralin is a novel Chordin-related molecule expressed in the mouse neural plate. Mech. Dev. 100, 119-122.
  • Brizuela, B.J., Wessely, O. and De Robertis, E.M. (2001). Overexpression of the Xenopus Claudin tight junction protein causes randomization of the left-right body axis. Developmental Biology 230, 217-229.
  • Wessely, O., Tran, U., Zakin, L. and De Robertis, E.M. (2001). Identification and expression of the mammalian homologue of Bicaudal-C. Mech. Dev. 101, 267-270.
  • De Robertis, E.M., Wessely, O., Oelgeschläger, M., Brizuela, B., Pera, E., Larraín, J., Abreu, J. and Bachiller, D. (2001). Molecular mechanisms of cell-cell signalling by Spemann’s organizer. Int. J. Dev. Biol. 45, 189-197. Preface to IJDB issue.
  • Wessely, O., Agius, E., Oelgeschläger, M., Pera, E.M. and De Robertis, E.M. (2001). Neural induction in the absence of mesoderm: -catenin dependent expression of secreted BMP antagonists at the blastula stage in Xenopus. Dev. Biol. 234, 161-173.
  • De Robertis, E.M. and Bouwmeester, T. (2001). New twists on embryonic patterning. EMBO Reports 21, 661-665.
  • Larraín, J., Oelgeschläger, M., Ketpura, N.I., Reversade, B., Zakin, L. and De Robertis, E.M. (2001). Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation on BMP. Development 128, 4439-4447.
  • Pera, E.M., Wessely, O., Li, S.Y. and De Robertis, E.M. (2001). Neural and head induction by Insulin-like Growth Factor signals. Developmental Cell 1, 655-665.
  • Larraín, J., Bachiller, D., Lu, B., Agius, E., Piccolo, S. and De Robertis, E.M. (2000). BMP-binding modules in Chordin: a model for signalling regulation in the extracellular space. Development 127, 821-830.
  • Agius, E., Oelgeschläger, M., Wessely, O. and De Robertis, E.M. (2000). Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development 127, 1173-1183.
  • Bachiller, D., Klingensmith, J., Kemp, C., Belo, J.A., Anderson, R.M., May, S.R., McMahon, J.A., McMahon, A.P., Harland, R., Rossant, J. and De Robertis, E.M. (2000). The organizer secreted factors Chordin and Noggin are required for forebrain development in the mouse. Nature 403, 658-661.
  • Belo, J.A., Bachiller, D., Agius, E., Kemp, C., Borges, A.C., Marques, S., Piccolo, S. and De Robertis, E. M. (2000). Cerberus-like is a secreted BMP and Nodal antagonist not essential for mouse development. Genesis 26, 265-270.
  • Wessely, O. and De Robertis, E.M. (2000). The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that regulates endoderm development. Development 127, 2053-2062.
  • Yamamoto, A., Kemp, C., Bachiller, D., Geissert, D. and De Robertis, E.M. (2000). Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development. Genesis 27, 49-57.
  • Oelgeschläger, M., Larraín, J., Geissert, D. and De Robertis, E.M. (2000). The evolutionary conserved BMP-binding protein Twisted Gastrulation promotes BMP signalling. Nature 405, 757-763.
  • Pera, E. and De Robertis, E.M. (2000). A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1. Mech. Dev. 96, 197-207.
  • Kim, S.H., Jen, W.C., De Robertis, E.M. and Kintner, C. (2000). The protocadherin PAPC establishes segmental boundaries during somitogenesis in Xenopus embryos. Curr. Biol. 10, 821-830.
  • De Robertis, E.M., Larraín, J., Oelgeschläger, M. and Wessely, O. (2000). The establishment of Spemann’s Organizer and patterning of the vertebrate embryo. Nature Reviews Genetics 1, 171-181.
  • Piccolo, S., Agius, E., Leyns, L., Battacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E.M. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.
  • Borello, U., Coletta, M., Tajbakhsh, S., Leyns, L., De Robertis, E.M., Buckingham, M. and Cossu, G. (1999). Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development 126, 4247-4255.
  • Agius, E., Piccolo, S. and De Robertis, E.M. (1999). Etudes épistatiques démontrant que l’inducteur cépalique Cerberus est un inhibiteur multivalent fonctionnant exclusivement dans l’espace extracellulaire. Journal de la Société de Biologie, Vol. 193 , 347-354.
  • Duprez, D., Leyns, L., Bonnin, M.A., Lapointe, F., Etchevers, H., De Robertis, E.M. and Le Douarin, N. (1999). Expression of Frzb-1 during chick development. Mech. Dev. 89, 179-183
  • Zhu, L., Belo, J.A., De Robertis, E.M. and Stern, C.D. (1999). Goosecoid regulates the neural inducing strength of the mouse node. Dev. Biol. 216, 276-281.
  • De Robertis, E.M. (1999). A nose for the embryo: the work of Pieter Nieuwkoop. Int. J. Dev. Biol.43, 603-604.
  • Konishi, Y., Tominaga, M., Watanabe, Y., Imamura, F., Goldfarb, A., Maki, R., Blum, M., De Robertis, E.M. and Tominaga, A. (1999). Goosecoid inhibits erythrocyte differentiation by competing with Rb for PU.1 binding in murine cells. Oncogene 18, 6795-6805.
  • Pillemer, G., Epstein, M., Blumberg, B., Yisraeli, J.K., De Robertis, E.M., Steinbeisser, H. and Fainsod, A. (1998). Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech. Dev. 71, 193-196.
  • Belo, J.A., Leyns, L., Yamada, G. and De Robertis, E.M. (1998). The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Mech. Dev.72, 15-26.
  • Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A.G., Moreno, T.A., Umesono, K., Perlmann, T., De Robertis, E.M. and Evans, R.M. (1998). BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev. 12, 1269-1277.
  • Yamamoto, A., Amacher, S.L., Kim, S.H., Geissert, D., Kimmel, C.B. and De Robertis, E.M. (1998). Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Development 125, 3389-3397.
  • Kim, S.H., Yamamoto, A., Bouwmeester, T., Agius, E. and De Robertis, E.M. (1998). The role of paraxial protocadherin in selective adhesion and cell movements of the mesodermal mantle during Xenopus gastrulation. Development 125, 4681-4691.
  • Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S. and De Robertis, E.M. (1997). Frzb-1 is a secreted antagonist of Wnt signalling expressed in the Spemann’s organiser. Cell 88, 747-756
  • De Robertis, E.M. (1997). The ancestry of segmentation. Nature387, 25-26
  • Piccolo, S., Agius, E., Lu, B., Goodman, S., Dale, L., and De Robertis, E.M. (1997) Cleavage of chordin by Xolloid Metalloprotease suggest a role for proteolytic processing in the regulation of Spemann organizer activity. Cell 91, 407-416.
  • Belo, J.A., Bouwmeester, T.,Leyns, L.,Kertesz, N., Gallo, M., Folletie, M. and De Robertis, E.M. (1997). Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68, 45-57.
  • Pfeffer, P.L., De Robertis, E.M. and Izpisúa-Belmonte, J.C. (1997). Crescent, a novel chick gene encoding a frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. Int. J. Dev. Biol. 41, 449-458.
  • Heanue, T.A., Johnson, R.L., Izpisúa-Belmonte, J.C., Stern, C.D., De Robertis, E.M. and Tabin, C.J. (1997) Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb buds. Mech. Dev. 69, 31-37.
  • De Robertis, E.M., Kim. S.H., Leyns, L., Piccolo, S., Bachiller, D., Agius, E., Belo, J.A., Yamamoto, A., Hainski-Brosseau, A., Brizuela, B., Wessely, O., Lu, B. and Bouwmeester, T. (1997). Patterning by genes expressed in Spemann’s organizer. Cold Spring Harbor Symp. Quant. Biol. 62, 169-175.
  • Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E.M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann’s Organizer. Nature 382, 595-601
  • Catala, M., Teillet, M.A., De Robertis, E.M. and Le Douarin, N.M. (1996). A spinal cord fate map in the avian embryo: while regressing, the Hensen’s node lays down the floor plate and notochord thus joining the spinal cord lateral walls. Development 122, 2599-2610
  • De Robertis, E.M. and Sasai, Y. (1996). A common plan for dorso-ventral patterning in Bilateria. Nature 380, 37-40.
  • Gont, L.K., Fainsod, A., Kim, S. and De Robertis, E.M. (1996). Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus. Developmental Biology, 174,174-178
  • Holley, S.A., Neul, J.L., Attisano, L., Wrana, J.L., Sasai, Y., O’Connor, M.B., De Robertis, E.M. and Ferguson, E.L. (1996). The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by blocking dpp signaling upstream of receptor activation. Cell 86, 607-617.
  • Piccolo, S., Sasai, Y., Lu, B. and De Robertis, E.M. (1996). Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of Chordin to BMP-4. Cell 86, 589-598
  • Sasai, Y., Lu, B., Piccolo, S. and De Robertis, E. (1996). Endoderm induction by the organizer secreted factors Chordin and Noggin in Xenopus animal caps. The EMBO J. 15, 4547-4555.
  • De Robertis, E.M. (1995). Dismantling the organizer. Nature 374, 407-408.
  • Yamada, G., Mansouri, A., Torres, M., Stuart, E.T., Blum, M., Schultz, M., De Robertis, E.M., and Gruss, P. (1995). Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death. Development 121, 2917-2922.
  • Holley, S.A., Jackson, P. D., Sasai, Y., Lu, B., De Robertis, E M., Hoffmann, F.M., and Ferguson, E.L. (1995). A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature 376, 249-253.
  • Sasai, Y., Lu, B., Steinbeisser, H., and De Robertis, E.M. (1995). Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376, 333-336.
  • Steinbeisser, H., Fainsod, A., Niehrs, C., Sasai, Y., and De Robertis, E.M. (1995). The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. Embo J. 14, 5230-5243.
  • Blum, M., De Robertis, E.M., Kojis, T., Heinzmann, C., Klisak, I., Geissert, D., and Sparkes, R.S. (1994). Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1. Genomics 21, 388-393.
  • Niehrs, C., Steinbeisser, H., and De Robertis, E.M. (1994). Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid. Science 263, 817-820.
  • Fainsod, A., Steinbeisser, H., and De Robertis, E.M. (1994). On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. Embo J. 13, 5015-5025.
  • Schulte-Merker, S., Hammerschmidt, M., Beuchle, D., Cho, K.W., De Robertis, E.M., and Nusslein-Volhard, C. (1994). Expression of zebrafish goosecoid and no tail gene products in wild- type and mutant no tail embryos. Development 120, 843-852.
  • De Robertis, E.M., Fainsod, A., Gont, L.K., and Steinbeisser, H. (1994). The evolution of vertebrate gastrulation. Dev. Suppl., 117-124.
  • Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L. K., and De Robertis, E.M. (1994). Xenopus chordin: a novel dorsalizing factor activated by organizer- specific homeobox genes. Cell 79, 779-790.
  • Pfeffer, P.L., and De Robertis, E.M. (1994). Regional specificity of RAR gamma isoforms in Xenopus development. Mech. Dev. 45, 147-53.
  • Steinbeisser, H., and De Robertis, E.M. (1993). Xenopus goosecoid: a gene expressed in the prechordal plate that has dorsalizing activity. C. R. Acad. Sc., Parisi 316, 959-971.
  • Steinbeisser, H., De Robertis, E.M., Ku, M., Kessler, D.S., and Melton, D.A. (1993). Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. Development 118, 499-507.
  • Bittner, D., De Robertis, E M., and Cho, K.W. (1993). Characterization of the Xenopus Hox 2.4 gene and identification of control elements in its intron. Dev. Dy.n 196, 11-24.
  • Izpisua-Belmonte, J.C., De Robertis, E.M., Storey, K.G., and Stern, C.D. (1993). The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell 74, 645-59.
  • Gaunt, S.J., Blum, M., and De Robertis, E.M. (1993). Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall. Development 117, 769-78.
  • Niehrs, C., Keller, R., Cho, K.W., and De Robertis, E.M. (1993). The homeobox gene goosecoid controls cell migration in Xenopus embryos. Cell 72, 491-503.
  • Gont, L.K., Steinbeisser, H., Blumberg, B., and de Robertis, E.M. (1993). Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development 119, 991-1004.
  • Jones, F.S., Holst, B.D., Minowa, O., De Robertis, E.M., and Edelman, G.M. (1993). Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3). Proc. Nat.l Acad. Sci. USA 90, 6557-61.
  • Storey, K.G., Crossley, J.M., De Robertis, E.M., Norris, W.E., and Stern, C.D. (1992). Neural induction and regionalisation in the chick embryo. Development 114, 729-741.
  • Blum, M., Gaunt, S.J., Cho, K.W., Steinbeisser, H., Blumberg, B., Bittner, D., and De Robertis, E.M. (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.
  • Jegalian, B.G., Miller, R.W., Wright, C.V., Blum, M., and De Robertis, E.M. (1992). A Hox 3.3-lacZ transgene expressed in developing limbs. Mech. Dev. 39, 171-180.
  • Jegalian, B.G., and De Robertis, E.M. (1992). Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene. Cell 71, 901-910.
  • Blumberg, B., Mangelsdorf, D.J., Dyck, J.A., Bittner, D.A., Evans, R.M., and De Robertis, E.M. (1992). Multiple retinoid-responsive receptors in a single cell: families of retinoid “X” receptors and retinoic acid receptors in the Xenopus egg. Proc. Natl. Acad. Sc. USA 89, 2321-2325.
  • Leroy, P., and De Robertis, E.M. (1992). Effects of lithium chloride and retinoic acid on the expression of genes from the Xenopus laevis Hox 2 complex. Dev. Dyn. 194, 21-32.
  • Niehrs, C., and De Robertis, E.M. (1992). Vertebrate axis formation. Curr. Opin. Genet. Dev. 2, 550-555.
  • Jones, F.S., Prediger, E.A., Bittner, D.A., De Robertis, E.M., and Edelman, G.M. (1992). Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Proc. Natl. Acad. Sc.i USA 89, 2086-2090.
  • Blumberg, B., Wright, C.V., De Robertis, E.M., and Cho, K.W. (1991). Organizer-specific homeobox genes in Xenopus laevis embryos. Science 253, 194-196.
  • Niehrs, C., and De Robertis, E.M. (1991). Ectopic expression of a homeobox gene changes cell fate in Xenopus embryos in a position-specific manner. Embo J. 10, 3621-3629.
  • De Robertis, E.M., Morita, E.A., and Cho, K.W. (1991). Gradient fields and homeobox genes. Development 112, 669-78.
  • Cho, K.W., Morita, E.A., Wright, CV., and De Robertis, E.M. (1991). Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells. Cell 65, 55-64.
  • Cho, K.W., Blumberg, B., Steinbeisser, H., and De Robertis, E.M. (1991). Molecular nature of Spemann’s organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.
  • De Robertis, E.M., Oliver, G., and Wright, C.V. (1990). Homeobox genes and the vertebrate body plan. Sc. Am. 263, 46-52.
  • Chuong, C.M., Oliver, G., Ting, S.A., Jegalian, B G., Chen, H.M., and De Robertis, E.M. (1990). Gradients of homeoproteins in developing feather buds. Development 110, 1021-1030.
  • Wright, C.V., Morita, E.A., Wilkin, D.J., and De Robertis, E.M. (1990). The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. Development 109, 225-234.
  • Molven, A., Wright, C.V., Bremiller, R., De Robertis, E.M., and Kimmel, C.B. (1990). Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. Development 109, 279-288.
  • Oliver, G., De Robertis, E.M., Wolpert, L., and Tickle, C. (1990). Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue. Embo J. 9, 3093-3099.
  • Jegalian, B.G., and De Robertis, E.M. (1990). The Xenopus laevis Hox 2.1 homeodomain protein is expressed in a narrow band of the hindbrain. Int. J. Dev. Biol. 34, 453-456.
  • Livingston, B.D., De Robertis, E.M., and Paulson, J.C. (1990). Expression of beta-galactoside alpha 2,6 sialyltransferase blocks synthesis of polysialic acid in Xenopus embryos. Glycobiology 1, 39-44.
  • Cho, K.W., and De Robertis, E.M. (1990). Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid. Genes Dev. 4, 1910-1916.
  • Wright, C. V., Schnegelsberg, P., and De Robertis, E.M. (1989). XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development 105, 787-794.
  • De Robertis, E.M., Oliver, G., and Wright, C.V. (1989). Determination of axial polarity in the vertebrate embryo: homeodomain proteins and homeogenetic induction. Cell 57, 189-191.
  • Wright, C.V., Cho, K.W., Hardwicke, J., Collins, R.H., and De Robertis, E.M. (1989). Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord. Cell 59, 81-93.
  • Fritz, A.F., Cho, K.W., Wright, C.V., Jegalian, B.G., and De Robertis, E.M. (1989). Duplicated homeobox genes in Xenopus. Dev. Biol. 131, 584-588.
  • Oliver, G., Sidell, N., Fiske, W., Heinzmann, C., Mohandas, T., Sparkes, R.S., and De Robertis, E.M. (1989). Complementary homeo protein gradients in developing limb buds. Genes Dev. 3, 641-650.
  • Wright, C. V., Cho, K. W., Oliver, G., and De Robertis, E. M. (1989). Vertebrate homeodomain proteins: families of region-specific transcription factors. Trends Biochem Sci 14, 52-6.
  • Cho, K.W., Goetz, J., Wright, C.V., Fritz, A., Hardwicke, J., and De Robertis, E.M. (1988). Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. Embo J. 7, 2139-2149.
  • Oliver, G., Wright, C.V., Hardwicke, J., and De Robertis, E.M. (1988). Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos. Embo J. 7, 3199-3209.
  • Oliver, G., Wright, C.V., Hardwicke, J., and De Robertis, E.M. (1988). A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos. Cell 55, 1017-1024.
  • De Robertis, E.M., Burglin, T.R., Fritz, A., Oliver, G., Cho, K., and Wright, C.V. (1988). Sequence conservations in vertebrate homeo-box mRNAs. Arc. Biol. Med. Exp. 21, 443-447.
  • Fritz, A., and De Robertis, E.M. (1988). Xenopus homeobox-containing cDNAs expressed in early development. Nucleic Acids Res. 16, 1453-1469.
  • Fritz, A.F., Martin, G., Wright, C.V., and De Robertis, E.M. (1988). Site-specific inversions in repeated Xenopus laevis homeobox gene 2 sequences. Nucleic Acids Res. 16, 9058.
  • Sharpe, C.R., Fritz, A., De Robertis, E.M., and Gurdon, J.B. (1987). A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction. Cell 50, 749-758.
  • Mattaj, I.W., Coppard, N J., Brown, R.S., Clark, B.F., and De Robertis, E.M. (1987). 42S p48–the most abundant protein in previtellogenic Xenopus oocytes– resembles elongation factor 1 alpha structurally and functionally. Embo J. 6, 2409-2413.
  • Wright, C.V., Cho, K.W., Fritz, A., Burglin, T.R., and De Robertis, E.M. (1987). A Xenopus laevis gene encodes both homeobox-containing and homeobox- less transcripts. Embo J. 6, 4083-4094.
  • Burglin, T.R., and De Robertis, E.M. (1987). The nuclear migration signal of Xenopus laevis nucleoplasmin. Embo J. 6, 2617-2625.
  • Burglin, T.R., Mattaj, I.W., Newmeyer, D.D., Zeller, R., and De Robertis, E.M. (1987). Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression. Genes Dev. 1, 97-107.
  • Burglin, T. R., Wright, C. V., and De Robertis, E. M. (1987). Translational control in homoeobox mRNAs? [letter]. Nature 330, 701-702.
  • Newmeyer, D.D., Lucocq, J.M., Burglin, T.R., and De Robertis, E.M. (1986). Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation. Embo J. 5, 501-510.
  • Mattaj, I.W., Lienhard, S., Jiricny, J., and De Robertis, E.M. (1985). An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes. Nature 316, 163-167.
  • Mattaj, I.W., and De Robertis, E.M. (1985). Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell 40, 111-118.
  • Mattaj, I.W., Zeller, R., Carrasco, A.E., Jamrich, M., Lienhard, S., and De Robertis, E.M. (1985). U snRNA gene families in Xenopus laevis. Oxf, Surv, Eukaryot, Genes 2, 121-140.